Estudio neuropsicológico de la dismorfia muscular y del trastorno obsesivo-compulsivo / Neuropsychological Study of Muscle Dysmorphia and Obsessive-Compulsive Disorder

Resumen El objetivo de este estudio fue explorar y comparar las funciones ejecutivas (FE) y la memoria no verbal de un grupo de varones fisicoconstructivistas con sintomatología de dismorfia muscular (DM), con un grupo de varones que presentan sintomatología del trastorno obsesivo-compulsivo (TOC) y un grupo de control. Aplicando pruebas neuropsicológicas se encontró que los fisicoconstructivistas muestran una capacidad limitada de las FE en el control inhibitorio y flexibilidad cognitiva, con déficits visuoespaciales moderados en la memoria no verbal, mientras que el grupo con TOC presentó mayores deficiencias de rendimiento en las mismas habilidades. Se sugiere realizar más estudios para evitar un conocimiento fragmentado o contradictorio entre la DM y el TOC.

Abstract The objective of this study was to explore and compare Executive Functions (EF) and non-verbal memory of a group of male bodybuilders who have symptoms of Muscle Dysmorphia (MD) with a group of men who have Obsessive Compulsive Disorder symptoms (OCD) and a control group. It was found by administering neuropsychological tests that the bodybuilders show a limited capacity of EF in the inhibitory control and cognitive flexibility, also moderate visuospatial deficits in non-verbal memory, whereas the group with OCD had higher performance deficiencies in the same skills. It is suggested to conduct more studies to avoid fragmented or contradictory knowledge between MD and OCD.

Non-suicidal self-injuries in a sample of Mexican university students / Autolesiones no suicidas en una muestra de estudiantes universitarios mexicanos

Abstract Introduction Non-suicidal self-injuries (NSSI) are a worldwide health problem that affects principally young people, and can impact negatively the mental and physical health of those that self-injure. Objective To examine the frequency of NSSI in 564 undergraduate students (132 male, 432 female) from Mexico City and the association of NSSI with depressive symptoms, anxiety, impulsivity, self-efficacy, and emotion regulation. Method A convenience sample of 564 undergraduate students (aged 17-26 years) from eight universities in the Mexico City metropolitan area completed a survey in their classrooms. Results Of the total sample, 30.9% had experimented at some point in their lifetime with NSSI on one to four occasions, while 26.9% had recurrent NSSI (i.e., five or more occasions). Nearly eleven percent self-injured in the prior 12 months. The NSSI most often reported among those who self-injured was cutting oneself (48.0%). Recurrent self-injurers reported higher levels of depression and impulsivity, and less self-efficacy than those who had experimented with such behaviors or without any lifetime NSSI. While 54.4% perceived the need for professional help, only 18.1% sought professional services. Discussion and conclusion NSSI is a hidden problem in the college population in Mexico City which needs to be addressed by university administrators and mental health professionals. Depressive symptomatology, impulsivity, and self-efficacy are factors that should be considered when developing preventive intervention strategies.

Resumen Introducción Las autolesiones no suicidas (ANS) son un problema mundial de salud que afecta principalmente a jóvenes, y puede impactar de manera negativa la salud mental y física de la persona que se autolesiona. Objetivo Examinar la frecuencia de ANS en 564 estudiantes de licenciatura (132 hombres, 432 mujeres) de la Ciudad de México y la asociación de las ANS con síntomas depresivos, ansiedad, impulsividad, autoeficacia y regulación emocional. Método Una muestra de conveniencia de 564 estudiantes universitarios (edades 17-26 años) de ocho universidades del área metropolitana de la Ciudad de México completó una encuesta en sus salones de clases. Resultados Del total de la muestra, 30.9% se habían infligido ANS de manera experimental de una a cuatro ocasiones, mientras que 26.9% presentaron ANS recurrentes (cinco o más ocasiones) en algún momento en su vida. Casi once por ciento reportaron ANS en los 12 meses previos. Las ANS reportadas con mayor frecuencia entre aquellos que se autolesionaron fueron cortarse a sí mismos (48.0%). Las personas con autolesiones recurrentes reportaron mayores niveles de depresión e impulsividad, y menos autoeficacia que aquellas que habían experimentado con estos comportamientos o sin ninguna historia de ANS en su vida. Aunque 54.4% percibían la necesidad de atención, solo 18.1% buscaron servicios profesionales. Discusión y conclusión Las ANS son una problemática oculta en la población universitaria de la Ciudad de México, la cual necesita ser atendida por las autoridades universitarias y los profesionales de la salud. La sintomatología depresiva, impulsividad y autoeficacia son factores que se deben considerar para desarrollar estrategias preventivas.

Adaptación y propiedades psicométricas del Inventory of Statements About Self-injury en estudiantes mexicanos / Adaptation and psychometric properties of the Inventory of Statements About Self-injury in Mexican students

Resumen La presente investigación evalúa las propiedades psicométricas de la adaptación al español del Inventory of Statements About Self-injury de Klonsky y Glenn (2009). Esta escala evalúa las diferentes motivaciones o funciones que las personas refieren para realizar autolesiones no suicidas. Se aplicó la escala en una muestra (N = 435) de alumnos universitarios de ambos sexos con una historia de autolesiones no suicidas. El análisis factorial confirmatorio detectó 7 factores interpretables (autorregulación, venganza, búsqueda de sensaciones/fortaleza, evitando el suicidio, manifestando angustia, autodeterminación y embotamiento), 5 más que el instrumento original. La confiabilidad de la escala fue aceptable, con un alfa de Cronbach de 0.89 para la escala total y de 0.72 a 0.82 para cada factor. Se presenta la validez convergente a través de correlaciones positivas entre la escala y mediciones de depresión, ansiedad e impulsividad. El instrumento adaptado al español presenta propiedades psicométricas aceptables para la medición de autolesiones no suicidas en población universitaria mexicana.

Abstract This research evaluates the psychometric properties of the Spanish language adaptation of the Inventory of Statements About Self-injury (Klonsky and Glenn, 2009). This scale assesses the motivations or functions that people with non-suicidal self-injuries report for engaging in self-injurious behaviors. The inventory was administered to a sample of 435 male and female university students with a lifetime history of non-suicidal self-injuries. A confirmatory factor analysis detected 7 interpretable factors (self-regulation, revenge, sensation seeking/toughness, avoiding suicide, marking distress, self-determination and numbness), 5 more than the original instrument. The scale had adequate internal consistency with a Cronbach's alpha of 0.89 and Cronbach's alphas of 0.72 to 0.82 for each factor. Positive correlations between the scale and measures of depression, anxiety and impulsivity suggest the convergent validity of the scale. Overall, the scale presents acceptable psychometric properties for the measurement of non-suicidal self-injuries in a Mexican university population.

Whole genome gene expression analysis reveals casiopeína-induced apoptosis pathways.

Copper-based chemotherapeutic compounds Casiopeínas, have been presented as able to promote selective programmed cell death in cancer cells, thus being proper candidates for targeted cancer therapy. DNA fragmentation and apoptosis-in a process mediated by reactive oxygen species-for a number of tumor cells, have been argued to be the main mechanisms. However, a detailed functional mechanism (a model) is still to be defined and interrogated for a wide variety of cellular conditions before establishing settings and parameters needed for their wide clinical application. In order to shorten the gap in this respect, we present a model proposal centered in the role played by intrinsic (or mitochondrial) apoptosis triggered by oxidative stress caused by the chemotherapeutic agent. This model has been inferred based on genome wide expression profiling in cervix cancer (HeLa) cells, as well as statistical and computational tests, validated via functional experiments (both in the same HeLa cells and also in a Neuroblastoma model, the CHP-212 cell line) and assessed by means of data mining studies.